Endocrine Abstracts

Introduction: Since there is no completely effective therapy available for malignant phaeochromocytomas (PCCs) and paragangliomas, we have been investigating novel targeted therapies utilising one more benign (MPC) and one more malignant (MTT) PCC cell line. We have previously shown that the IGF1-receptor-inhibitor NVP-AEW541 led to compensatory ERK and mTORC1 up-regulation at suboptimal doses and that the dual PI3K/mTORC1-inhibitor NVP-BEZ235 also resulted in compensatory ERK...

In chronic inflammatory disease, an increased proportion of M1 polarised macrophages have been shown to contribute to inflammation and tissue damage through the production of pro-inflammatory cytokines such as TNFα. Previously, we have identified expression of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids (GCs) to their active counterparts, in M1 polarised macrophages in vivo. We hypothesised that 11β...

To evaluate the prevalence of comorbilities related to acromegaly and the grade of response to the different therapeutic alternatives.Material-methods: A retrospective study of 25 acromegalic patients diagnosed between 1990–2010 was made. It included a descriptive analysis on sex, age, hypertension, impaired glucose metabolism when diagnosed acromegaly, screening for dygestive and cardiac pathology, tumoral size, and percentage of disease control an...

Introduction: Patients with severe cerebral Trauma are a risk population for developing hipopituytarism. Diagnosis of GHD need to study pituitary gland reserve with a stimulation test. Insulin Tolerance test (ITT) is the best standard test, although has important contraindication in these patients and its realization is not always a possible. We evaluate the diagnostic capacity of two alternative test (Glucagon Test an GHRH-GHRP6 test) and compared them with ITT.<p class="...

Somatostatin analogs (SSAs) such as octreotide (OCT) are currently effective in controlling most hypersecretion associated symptoms of Gastoenteropancreatic-neuroendocrinetumors (GEP-NETs). The results of the phase IIIb PROMID trial showed that OCT doubled time to progression for patients with metastatic neuroendocrine midgut tumors compared with placebo. SSAs act on different intracellular pathways through different somatostatin receptor (Sst) subtypes. While OCT is mainly an...

Papillary thyroid carcinoma (PTC), the most frequent thyroid cancer, has low proliferation but no apoptosis, presenting frequent lymph-node metastasis (Ordonez et al., 2004).SMAD3 has two opposite phosphorylation sites: the TGF-βRI–induced C-terminal Serine SMAD3 phosphorylation and the phosphorylation induced by CDK2 (T8, T179 and S213) and ERK (T179, S204, S208) (Wang et al. 2005, Matsuura et al. 2005).<p class=...